In the same way that the genetic movement profile, or indeed the movement profile itself, varies from individual to individual, so does the health profile. And this also applies to the diseases which manifest themselves as dementia. According to the latest scientific findings, the APOE (Apolipoprotein E) gene variant is a reliable indicator of whether someone is susceptible to Alzheimer’s disease or not. If we diagnose the APOE4 variant, then the risk of developing dementia rises by a factor of 9.2 compared with the APOE2 variant. It is important that the genetic test is carried out early, because Alzheimer’s dementia may be detected and diagnosed only after it has been developing for around twenty years, by which stage a cure is not possible given today’s knowledge of medicine.
Therefore, prevention is the only way to counter the disease. So when we detect the APOE4 gene variant in one of our clients at an early stage, we recommend cognitive training. Neurologists tell us that, even at an advanced age, people are able to form new neurons. From the genotype, we can identify the part of the brain in which the density of nerve cells will decrease, leading to the development of dementia.
The client then receives from us software-assisted cognitive training which is adapted specifically to his or her genetic structure. The effect is that new neurons are formed in the precise area of the brain where nerve cell density is set to decrease, thereby halting the trend towards dementia. The time that our clients are expected to devote to this is around three minutes per day. The system has been developed by a Swiss university and, taken in conjunction with the gene check, is the only way to prevent the disease.
Monday, December 28, 2015
Sunday, December 27, 2015
Good cholesterol
In recent years, we have had it drummed into us that there is an important distinction to be made between different kinds of cholesterol. On the one hand, there is the so-called “good” variety – high-density lipoprotein (HDL) non-oxidized cholesterol – and we should keep its level high. On the other hand, there is so-called “bad cholesterol” – low-density lipoprotein (LDL) cholesterol – the level of which should be kept low.
Consequently, it is not enough to state baldly that someone has a high overall cholesterol level.
Recently, a gene has been identified which provides information about whether we have a genetically determined high HDL level. And we also know what can be done if a person does not have this beneficial gene variant: by taking certain combinations of vitamins, it is possible to increase the level of good cholesterol. As a corollary, it is possible to mitigate the effect of the “less good” genotype by means of a change in lifestyle, i.e. diet or vitamin supplements. But of course, you have to know your genes first.
Consequently, it is not enough to state baldly that someone has a high overall cholesterol level.
Recently, a gene has been identified which provides information about whether we have a genetically determined high HDL level. And we also know what can be done if a person does not have this beneficial gene variant: by taking certain combinations of vitamins, it is possible to increase the level of good cholesterol. As a corollary, it is possible to mitigate the effect of the “less good” genotype by means of a change in lifestyle, i.e. diet or vitamin supplements. But of course, you have to know your genes first.
Saturday, December 26, 2015
Whole food
If someone has a genetic predisposition to diabetes, it means that simple carbohydrates such as potatoes, white rice or pasta may trigger the disease. This sort of person needs to switch to whole-grain products. For others, it is less important. People who are susceptible to obesity, on the other hand, should cut down on fiber-rich products because – for example – a slice of pumpernickel has the same energy density as eight slices of toast and yet they are tempted to consume the same volume as before.
Friday, December 25, 2015
Chronobiology (Slimming while you sleep)
It turns out that nutritional medicine may have to be rewritten. Firstly, due to genetic predisposition, because healthy eating is something different for everyone, and secondly, because of two further key issues.
The first of these is insulin. Insulin is what the pancreas secretes when we eat and digest something.
The other is chronobiology, i.e. timing: When do we eat what? And that’s what is so intriguing, the fact that we have to pay attention to two distinct aspects. First of all, what causes insulin to be secreted? There are a few things here that we simply have to reformulate. Quite a lot has gone wrong on this front in recent years. And the second aspect is quite crucial: at what time of the day should we eat which foods? That’s because the pancreas reacts in different ways depending on the time of day. And this is regardless of our individual daily routine. The science of chronobiology is the science of the body clock.
We humans have time slots for certain wake and sleep phases. We have time slots in which we regenerate ourselves. We have time slots to metabolize certain substances or to consume certain foods. To this extent, we now know when the body is doing what. It’s about the time of day we engage in sport or sit down to eat. Nowadays, we generally manage quite well on this score and are able, for example, to get on top of an existing diabetes condition – that’s partly why this has become so well known. It’s about controlling the pancreas in such a way that it fulfills its chronobiological function. This essentially means carbohydrates in the morning, a balanced diet at lunchtime and mainly protein intake in the evening. At the same time, the genetics of the individual have to be taken into account – which protein, which carbohydrates, etc. We know that, as long as the individual broadly complies with this diet, weight gain can be almost ruled out and the momentum towards diabetes can be halted.
The first of these is insulin. Insulin is what the pancreas secretes when we eat and digest something.
The other is chronobiology, i.e. timing: When do we eat what? And that’s what is so intriguing, the fact that we have to pay attention to two distinct aspects. First of all, what causes insulin to be secreted? There are a few things here that we simply have to reformulate. Quite a lot has gone wrong on this front in recent years. And the second aspect is quite crucial: at what time of the day should we eat which foods? That’s because the pancreas reacts in different ways depending on the time of day. And this is regardless of our individual daily routine. The science of chronobiology is the science of the body clock.
We humans have time slots for certain wake and sleep phases. We have time slots in which we regenerate ourselves. We have time slots to metabolize certain substances or to consume certain foods. To this extent, we now know when the body is doing what. It’s about the time of day we engage in sport or sit down to eat. Nowadays, we generally manage quite well on this score and are able, for example, to get on top of an existing diabetes condition – that’s partly why this has become so well known. It’s about controlling the pancreas in such a way that it fulfills its chronobiological function. This essentially means carbohydrates in the morning, a balanced diet at lunchtime and mainly protein intake in the evening. At the same time, the genetics of the individual have to be taken into account – which protein, which carbohydrates, etc. We know that, as long as the individual broadly complies with this diet, weight gain can be almost ruled out and the momentum towards diabetes can be halted.
Wednesday, December 23, 2015
The interaction of genes and diet, taking broccoli as an example
Today, we explore a fascinating topic, namely the interaction of genes and nutrition. Everyone can do something about their diet. For a start, we have a genetic predisposition which determines what diet really suits us and keeps us slim and healthy.
But we now know that it goes the other way too, with nutrition affecting the genes. Namely, whether genes activate themselves or stay inactive. This is a fascinating story, and colleagues from Johns Hopkins University in the USA have made a great discovery. Take, for example, a patient with a chronic lung condition in whom a particular gene is inactive and this inactivity means that fewer toxins are excreted from the body. Now we have this sensational discovery: substances found in broccoli can activate this gene and thus promote the excretion of the toxins that are the root cause of this disease.
There are many more examples where diet influences the activity of genes. Healthy eating is different for each individual because of his or her genes.
But we now know that it goes the other way too, with nutrition affecting the genes. Namely, whether genes activate themselves or stay inactive. This is a fascinating story, and colleagues from Johns Hopkins University in the USA have made a great discovery. Take, for example, a patient with a chronic lung condition in whom a particular gene is inactive and this inactivity means that fewer toxins are excreted from the body. Now we have this sensational discovery: substances found in broccoli can activate this gene and thus promote the excretion of the toxins that are the root cause of this disease.
There are many more examples where diet influences the activity of genes. Healthy eating is different for each individual because of his or her genes.
Tuesday, December 22, 2015
How do we keep ourselves healthy and fit?
The decisive factor is attitude! I recently held an event attended by around 100 people and asked them what was the most important thing for them in life.
There are obviously different responses to this question: my car, my children, my partner or spouse etc. The answers could be divided into three groups. One group responded spontaneously and without hesitation: “My health, of course.” Without good health, nothing else matters much anyway. The second group (almost all Spaniards) replied: “My family.” The third group came up with a range of different answers.
Very important: If you want to stay healthy in a systematic way rather than simply by chance, then this issue cannot be ignored. We sometimes even ask potential clients who are considering us as health advisors how important this matter is to them and the extent to which they are willing to invest time and money in it. So, consider your own attitude first and weigh up how important your health is to you.
There are obviously different responses to this question: my car, my children, my partner or spouse etc. The answers could be divided into three groups. One group responded spontaneously and without hesitation: “My health, of course.” Without good health, nothing else matters much anyway. The second group (almost all Spaniards) replied: “My family.” The third group came up with a range of different answers.
Very important: If you want to stay healthy in a systematic way rather than simply by chance, then this issue cannot be ignored. We sometimes even ask potential clients who are considering us as health advisors how important this matter is to them and the extent to which they are willing to invest time and money in it. So, consider your own attitude first and weigh up how important your health is to you.
Monday, December 21, 2015
Detoxification
Pollution in the air, in water and in food is absorbed by the body and must be neutralized. That’s on top of all the toxins that we take in through choice, such as tobacco smoke (both active and passive) or smoked/grilled meats. Added to which we have numerous harmful substances in our body that arise from metabolic processes.
The vital detoxification functions are controlled by our own genetic structure. We all detoxify in a different way. Everyone has his or her own genetic detoxification profile and produces different amounts of certain detoxification enzymes or, in the worst case scenario, none at all.
I therefore advise my clients as to how they should compensate for lack of detoxification enzymes by adopting a certain diet or by taking supplementary vitamins.
For example, if a client has one particular existing genotype, too few cancer-preventing enzymes are being produced, or possibly none at all. In such a case, I recommend the consumption of cruciferous plants such as red or green cabbage, broccoli, parsley and watercress, or even taking broccoli capsules if the client does not like these vegetables. In this way, the client achieves the same detoxification effect as if he or she had the so-called “good” gene variant. It is therefore important for the client to know his or her genetic profile. Only then can we supply the missing genetic protection – e.g. by nutritional balance – and prevent the onset of diseases.
The vital detoxification functions are controlled by our own genetic structure. We all detoxify in a different way. Everyone has his or her own genetic detoxification profile and produces different amounts of certain detoxification enzymes or, in the worst case scenario, none at all.
I therefore advise my clients as to how they should compensate for lack of detoxification enzymes by adopting a certain diet or by taking supplementary vitamins.
For example, if a client has one particular existing genotype, too few cancer-preventing enzymes are being produced, or possibly none at all. In such a case, I recommend the consumption of cruciferous plants such as red or green cabbage, broccoli, parsley and watercress, or even taking broccoli capsules if the client does not like these vegetables. In this way, the client achieves the same detoxification effect as if he or she had the so-called “good” gene variant. It is therefore important for the client to know his or her genetic profile. Only then can we supply the missing genetic protection – e.g. by nutritional balance – and prevent the onset of diseases.
Sunday, December 20, 2015
Red wine
Red wine can be healthy. Certain people who have a specific genetic predisposition can benefit from the consumption of red wine in a number of ways. We also have the findings from a study conducted some time ago which was called “The French Paradox”. It showed that the French have 40% fewer heart attacks, even though they smoke just as much as Americans and consume the same amount of fat.
More recent and broadly based studies have shown that this is partly attributable to the consumption of red wine.
People with a specific genetic predisposition benefit in many ways from the consumption of red wine:
red wine increases protection against heart and circulatory disease
red wine increases HDL (“good”) cholesterol
red wine offers increased protection against atherosclerosis
red wine has anti-inflammatory properties
red wine significantly boosts insulin metabolism
red wine helps fight stomach ulcers, because it kills off the Helicobacter bacterium
red wine significantly reduces susceptibility to dementia
red wine contains the sleep hormone melatonin and thus actively aids sleep
Red wine also has life-prolonging properties. The Medical School in the USA has found that a certain plant compound in red wine called resveratrol activates certain longevity genes, in particular the SIR2 gene.
More recent and broadly based studies have shown that this is partly attributable to the consumption of red wine.
People with a specific genetic predisposition benefit in many ways from the consumption of red wine:
red wine increases protection against heart and circulatory disease
red wine increases HDL (“good”) cholesterol
red wine offers increased protection against atherosclerosis
red wine has anti-inflammatory properties
red wine significantly boosts insulin metabolism
red wine helps fight stomach ulcers, because it kills off the Helicobacter bacterium
red wine significantly reduces susceptibility to dementia
red wine contains the sleep hormone melatonin and thus actively aids sleep
Red wine also has life-prolonging properties. The Medical School in the USA has found that a certain plant compound in red wine called resveratrol activates certain longevity genes, in particular the SIR2 gene.
Wednesday, December 16, 2015
Omega-3
Depending on individual genetic disposition, fish – in particular omega-3 fish oils – has excellent health effects on some people while triggering health problems in others.
Fish, especially omega-3, is healthy for people who have the relevant variant on their APOA1 gene. APOA1 is a well-known gene, and such people benefit from a cholesterol-lowering effect; furthermore, they have exceptional protection against atherosclerosis and other cardiovascular diseases. With their gene variant, they can also benefit from blood-thinning and anti-inflammatory effects. That’s why people with this gene variant should eat a lot of oily fish – maybe once a week salmon or mackerel – and also vegetable oils such as olive oil.
By contrast, fish oils are unhealthy for people who have the mutation G to G in this same gene. These people have the disadvantage that their level of HDL cholesterol (i.e. the “good” variety) is significantly reduced, thus increasing the risk of cardiovascular disease. Intake of polyunsaturated vegetable oils, for example olive oil, should not be unnecessarily increased. This applies in particular for women. In all matters concerning diet, genetic predisposition is decisive, and this is why genetic testing is advisable.
Fish, especially omega-3, is healthy for people who have the relevant variant on their APOA1 gene. APOA1 is a well-known gene, and such people benefit from a cholesterol-lowering effect; furthermore, they have exceptional protection against atherosclerosis and other cardiovascular diseases. With their gene variant, they can also benefit from blood-thinning and anti-inflammatory effects. That’s why people with this gene variant should eat a lot of oily fish – maybe once a week salmon or mackerel – and also vegetable oils such as olive oil.
By contrast, fish oils are unhealthy for people who have the mutation G to G in this same gene. These people have the disadvantage that their level of HDL cholesterol (i.e. the “good” variety) is significantly reduced, thus increasing the risk of cardiovascular disease. Intake of polyunsaturated vegetable oils, for example olive oil, should not be unnecessarily increased. This applies in particular for women. In all matters concerning diet, genetic predisposition is decisive, and this is why genetic testing is advisable.
Wednesday, December 9, 2015
Does milk boost energy, and is milk healthy for everyone?
Healthy eating means something different for everyone. It is always the individual’s “own” genes that determine what is healthy. Of two people following the same diet, one may lose weight while the other puts it on. Milk can energize and vitalize, but it can also cause fatigue and illness.
People with a particular gene variant – the so-called 9q34 gene – can fully benefit from the positive properties of dairy products, namely muscle-building properties, increased vitality and higher bone density. On the other hand, milk is unhealthy for a large part of the population who have a particular variant of another gene, 9q34. For people with such a gene variant, milk is unsuitable for the adequate supply of calcium and vitamin D because of the very unfavorable calcium phosphate content.
Furthermore, they suffer disproportionately from intolerance to lactose and develop antibodies to certain milk proteins such as casein. This has a highly adverse effect on the hormone balance, and also on the neurotransmitters. Milk tends to make such people feel tired and can even lead to depression.
People with a particular gene variant – the so-called 9q34 gene – can fully benefit from the positive properties of dairy products, namely muscle-building properties, increased vitality and higher bone density. On the other hand, milk is unhealthy for a large part of the population who have a particular variant of another gene, 9q34. For people with such a gene variant, milk is unsuitable for the adequate supply of calcium and vitamin D because of the very unfavorable calcium phosphate content.
Furthermore, they suffer disproportionately from intolerance to lactose and develop antibodies to certain milk proteins such as casein. This has a highly adverse effect on the hormone balance, and also on the neurotransmitters. Milk tends to make such people feel tired and can even lead to depression.
Wednesday, December 2, 2015
The jet lag rules (general)
- Drink lots of non-fluoridated water, reverse osmosis water, or spring water
- Avoid all alcohol three days before during and three days after your trip.
- Never sit next to a window with an open curtain. You are getting excessive UVA exposure and getting more cosmic radiation, both of which lead to higher Vitamin A levels in the brain, lower Vitamin D levels in the skin and brain, and much high risk of developing skin damage from the excessive UVA. You also risk high cataract exposure if you are a frequent flyer.
- Always sit in the aisle so you can get up and move.
- Always connect your foot to the metal framework in front of you to ground yourself to the plane.
- Always use noise reduction ear plugs.
- Never sit in the emergency row. It has all the avionics of the wings close to it and has higher EMF risks.
- Wear blue blockers during flight to preserve your DHA loss in your eye and skin.
- Always eat a large seafood meal before getting on a flight. Dose yourself with ubiquinol before during and after the flight. Try to fast during the flight and after you land. The following day eat a very large breakfast. I try to make sure it is ketogenic and DHA deep. Being ketogeneic limits lactic acid build up and the seafood omelets replenish the lost DHA. Some people use bicarbonate to limit lactic acid build up but I have not had success with it.
If you’re heading east, aim for an evening arrival to minimize the circadian disruption. This all helps- you align with the new time schedule.
- Before your trip, ease your transition to the new time zone by moving your bedtime. The American Academy of Sleep Medicine guidelines suggest shifting your sleep schedule an hour earlier each night, starting three days before you leave on an eastbound trip. For me traveling to medical conferences, this is impractical. Instead, I try to go to bed 15 minutes earlier each night, and get as much early-morning sunlight outside scantily clad as I can.Natural light is the most potent tool for adjusting your body clock: natural light releases cortisol to unzip collagen and allow cells in the brain to swell by altering slow and fast water flows via aquaporin 4 to wake you up naturally. Light is akin to a medication that wakes you up. It does the same thing as modafinil does to your CNS. Aquaporin 4 undergoes elastic deformation during flights and can lead to “gate issues” for water flow in the brain. Some people have used low dose calcium channel blockade drugs when it becomes clear calcium efflux is stimulatory to their brain causing headaches. This can lead to calcium homeostasis in a neuron to cause swelling. This leads to an inability to restore extracellular water levels to maintain water battery after neuronal and glial cell swelling in response to stimulus of light which can act to crash the system. When you generate an irregular function at the AQA4 gates, you create an energy supply problem. This leads to an irregular metabolism in neurons, but specifically their mitochondrial function lessens because it swells. This leads to fluctuating demand for nutrients to maintain mitochondrial mass. When energy balance is off, it leads to fluctuating ability to sense both the internal and external environment. This is why jet lag is often seen with cognitive decline and exacerbates mental illness. When autophagy is lowered, we develop an altered capacity for “pro-survival/intelligent” choices. This is manifest by irregular dopamine cycling which leads to moodiness, cognitive haze and poor decision making. This is why I also map out my jet lag plan on paper before I fly so I won’t go off schedule if I feel bad when I arrive.
- If you’re headed west, expose yourself to natural light at sunset in the evening before you leave 3 days before the flight. I told this to some professional football players many years ago to offset their poor play on the west coast after they fly from the east coast of the US. They were shocked at how well it reversed their recent play as the traveled time zones. This hack can morph your body clock into thinking it’s morning when it is not. Sunshine is ideal, but those sun-mimicking lights designed to counter seasonal affective disorder are a good stand-in. I have also toyed around with red light and with 380 nm light in my hacks and they have been successful in very long flights while going west.
If you are going eastward a 15 minute brisk walk of a few 40 yd sprints helps. If it is cold, that is even better. Though its effects are much weaker than those of light, exercise (especially when vigorous) has a similar influence and can make you feel more alert. Both of these hacks stimulate autophagy.
- Swimming in cold water is one of the best hacks for long eastward trips. I also use the “Kruse hack” for jet lag going eastward by lying face down on the diving board of the pool and putting my hands and wrists in the cold water while also putting my head face down below the diving board platform before diving in. I do this because my head is then below my heart and it increases blood flow to my brain, increasing CMRO2 which also stimulates autophagy. This offsets the effect of microgravity of the flight. This also offsets the loss of gravity from the flight. Gravity is affected by two main factors – latitude and altitude. Plane flight brings both of these into play for our biology and we forget it. Low latitudes are the latitudes between the Tropic of Cancer and Capricorn. Portions of the low latitudes receive direct sunlight year round, therefore there is a constant source of infrared energy to maximally form an Exclusion Zone from water. This is not true at the poles. Water is a repository for electromagnetic energy. Water absorbs energy best in the infrared range. At the poles, there is far more cosmic and solar radiation present. This type of radiation carries way more energy than infrared waves. This is why temperature lowers at the poles to offset the loss of infrared heat. Cold increases electron density in water to offset the energy loss, but is it enough to affect your weight or circadian biology? It actually is, but few know it.
- If you were to stand on one of the two poles on Earth then you would weigh 0.5 per cent more than if you were on the equator. Remember, when you weigh more, it means you are losing energy to the environment for some reason. Flying is a circadian mismatch that causes that loss of energy.
Telomer length and Melanomia
An international research consortium has found that longer telomeres increase the risk of melanoma.
Telomeres are a part of the genome that function like the plastic caps of your shoelaces, which prevent the laces from fraying. Instead they protect the ends of chromosomes from environmental damage, such as exposure to smoke or sunlight, which can harm them.
The GenoMEL study, conducted at the University of Leeds, looked at 11,108 melanoma cases and 13,933 control cases from Europe, Israel, United States and Australia. It is the largest study to date to trace the genetic basis of telomere length in melanoma. It evaluated seven known or suspected genetic variations (also called SNPS) in a genome-wide associate study (GWAS). It showed a strong association between telomere length and increased risk of melanoma.
“For the first time, we have established that the genes controlling the length of these telomeres play a part in the risk of developing melanoma,” said lead author of the study Mark Iles, PhD, School of Medicine at the University of Leeds (UK).
“Telomere length plays a key role in survival of cells and shorter telomere lengths are associated with aging and cardiovascular disease along with many cancers,” said Christopher Amos, PhD, co-author and associate cancer center director for population sciences and interim deputy director at the Dartmouth-Hitchcock Norris Cotton Cancer Center, Lebanon, NH.
The research team created a score representing genetically-determined telomere length, based on all the established telomere-associated genes and found that this score was associated with melanoma risk. The one in four people predicted to have the longest telomeres are at a 30 percent increased risk of developing melanoma compared to those one in four predicted to have the shortest telomeres.
The explanation for why a longer telomere is connected to melanoma is not yet known. Researchers propose that having a longer telomere may delay a cellular aging process, which increases the likelihood cellular variation.
“This research is important because it suggests that abnormal cell life span could play a key role in the development of melanomas and that agents targeting cell proliferation could be valuable for reducing melanoma growth,” said Amos.
“More research is needed to better understand the relationship between melanoma and telomeres, but learning more about how an individual’s genetic telomere profile influences their risk developing melanoma may help us,” said Iles. “It will improve our understanding of melanoma biology and gives us a target towards developing potential treatments as well as potentially helping shape advice on what behavioral changes people might make.”
Telomeres are a part of the genome that function like the plastic caps of your shoelaces, which prevent the laces from fraying. Instead they protect the ends of chromosomes from environmental damage, such as exposure to smoke or sunlight, which can harm them.
The GenoMEL study, conducted at the University of Leeds, looked at 11,108 melanoma cases and 13,933 control cases from Europe, Israel, United States and Australia. It is the largest study to date to trace the genetic basis of telomere length in melanoma. It evaluated seven known or suspected genetic variations (also called SNPS) in a genome-wide associate study (GWAS). It showed a strong association between telomere length and increased risk of melanoma.
“For the first time, we have established that the genes controlling the length of these telomeres play a part in the risk of developing melanoma,” said lead author of the study Mark Iles, PhD, School of Medicine at the University of Leeds (UK).
“Telomere length plays a key role in survival of cells and shorter telomere lengths are associated with aging and cardiovascular disease along with many cancers,” said Christopher Amos, PhD, co-author and associate cancer center director for population sciences and interim deputy director at the Dartmouth-Hitchcock Norris Cotton Cancer Center, Lebanon, NH.
The research team created a score representing genetically-determined telomere length, based on all the established telomere-associated genes and found that this score was associated with melanoma risk. The one in four people predicted to have the longest telomeres are at a 30 percent increased risk of developing melanoma compared to those one in four predicted to have the shortest telomeres.
The explanation for why a longer telomere is connected to melanoma is not yet known. Researchers propose that having a longer telomere may delay a cellular aging process, which increases the likelihood cellular variation.
“This research is important because it suggests that abnormal cell life span could play a key role in the development of melanomas and that agents targeting cell proliferation could be valuable for reducing melanoma growth,” said Amos.
“More research is needed to better understand the relationship between melanoma and telomeres, but learning more about how an individual’s genetic telomere profile influences their risk developing melanoma may help us,” said Iles. “It will improve our understanding of melanoma biology and gives us a target towards developing potential treatments as well as potentially helping shape advice on what behavioral changes people might make.”
What are Telomers?
Telomeres are the ends of chromosomes, which have an essential role in protecting their integrity in the process of cellular replication. One common analogy is that they are like the plastic caps at the end of shoe laces which keep the laces from unraveling. Telomeres are formed by tandem repeats of a DNA sequence, which is highly conserved (TTAGGG in vertebrates) and associated proteins (the so-called telomere-binding proteins or “shelterins”). The function of telomeres is to protect chromosome ends from chromosome fusions and degradation, therefore, ensuring the proper functionality and viability of cells. Why are telomeres important?
Cells stop duplicating when telomeres become too short. Therefore telomere length is considered to be an excellent biomarker of tissue renewal capacity and, consequently, of organismal aging. Telomeres progressively shorten with increasing age as a consequence of cumulative cycles of cell division that are required for tissue repair and regeneration. This occurs both in differentiated cells as well as in the stem cell compartments, and this shortening has been demonstrated to impair the ability of stem cells to regenerate tissues when needed. There is strong evidence from genetically modified mouse models demonstrating that accumulation of critically short telomeres is sufficient to cause organismal aging. lntervention that decrease the rate of telomere shortening with age, such as forced expression of the telomere-synthetizing enzyme telomerase, is also sufficient to delay aging and increase longevity. Thus, therapeutic strategies based on telomerase activation are envisioned as potentially important for intervening in age-related problems. Telomeres and telomerase are also relevant for cancer biology. More than 85% of all types of tumors activate telomerase during their formation in order to achieve immortality. Telomerase is, therefore, considered necessary to sustain cancer growth. Therapies aimed at inhibiting telomerase activity are currently tested in clinical trials of various types of human tumors.
Cells stop duplicating when telomeres become too short. Therefore telomere length is considered to be an excellent biomarker of tissue renewal capacity and, consequently, of organismal aging. Telomeres progressively shorten with increasing age as a consequence of cumulative cycles of cell division that are required for tissue repair and regeneration. This occurs both in differentiated cells as well as in the stem cell compartments, and this shortening has been demonstrated to impair the ability of stem cells to regenerate tissues when needed. There is strong evidence from genetically modified mouse models demonstrating that accumulation of critically short telomeres is sufficient to cause organismal aging. lntervention that decrease the rate of telomere shortening with age, such as forced expression of the telomere-synthetizing enzyme telomerase, is also sufficient to delay aging and increase longevity. Thus, therapeutic strategies based on telomerase activation are envisioned as potentially important for intervening in age-related problems. Telomeres and telomerase are also relevant for cancer biology. More than 85% of all types of tumors activate telomerase during their formation in order to achieve immortality. Telomerase is, therefore, considered necessary to sustain cancer growth. Therapies aimed at inhibiting telomerase activity are currently tested in clinical trials of various types of human tumors.
The 3 dimensions of the genetic code (Telomer)
Along with the media and the general public around the world, we were fascinated by the publication of the human genome in 2001. The findings were revolutionary in their implications: not only are our genes unique but also the process by which we can maintain our health. There is an infallible method: Identifying the right way of living for our genetic predisposition. This involves a combination of data processing, biological sciences, nanotechnology and computerized proteomics that will allow new interventions (not always predictable in their consequences) in the development of homo sapiens, a species that is not the final stage of evolution but only an intermediate product along the way.
But it is not only the first genetic code that has such great influence on our health and wellbeing; the second code has probably a much more decisive say in how we age and what influences we have on this process. As a result of changing dietary habits and of permanent access to calories, the epigenetic regulatory mechanisms have changed, the insulinogenic ‘second messengers’ have been over-expressed and thus also the anthropomorphic parameters. And last but not least, our understanding of gestation, as more and more details become known of the signal molecules that are necessary in the critical development phases for certain organs. Prolactin and progesterone are typical examples. And here, science has been enriched by a new and fascinating area: after the decryption of the genetic code and after the exploration of the epigenetic function marking of our genome (a work still in progress), we are now turning to the decryption of the third code, namely that of gestation. Taking all of this together and adding the latest biochemical markers such as telomere lengths, it is now possible to develop a sophisticated individualized age prevention strategy, and that is precisely the target that we have set ourselves on behalf of each and every one of our clients.
But it is not only the first genetic code that has such great influence on our health and wellbeing; the second code has probably a much more decisive say in how we age and what influences we have on this process. As a result of changing dietary habits and of permanent access to calories, the epigenetic regulatory mechanisms have changed, the insulinogenic ‘second messengers’ have been over-expressed and thus also the anthropomorphic parameters. And last but not least, our understanding of gestation, as more and more details become known of the signal molecules that are necessary in the critical development phases for certain organs. Prolactin and progesterone are typical examples. And here, science has been enriched by a new and fascinating area: after the decryption of the genetic code and after the exploration of the epigenetic function marking of our genome (a work still in progress), we are now turning to the decryption of the third code, namely that of gestation. Taking all of this together and adding the latest biochemical markers such as telomere lengths, it is now possible to develop a sophisticated individualized age prevention strategy, and that is precisely the target that we have set ourselves on behalf of each and every one of our clients.
Cancer and Epigenetics
Oncology believes “bad genes” cause brain cancer: Implicit in this belief is the assumption that to get cancer or illness you must have a mutated gene. This is what we call genetic determinism. What they miss is that genetic expression is altered by the electromagnetic signals coming from RNA and DNA and the non-ionizing frequency EMF bands do change this information processing that occurs in the hydration shell around our nucleic acids. They are not studying this aspect of the cellular communication system because they do not understand the physics of biology. Nor are they studying how hydrated electrified proteins work normally, while dehydrated proteins have abnormal function because calcium levels and oxygen levels are altered and set the stage for brain cancer to occur.
Volkow and Achermann both showed definitively that brain physiology is changed by up-regulating glucose metabolism with respect to non native EMF. Both of their studies are the best we have in reference to this specific issue in the published literature. Brain tumors have risen 500% over the last 50 years and no one seems to know why. Our third researcher, Bissell, a breast cancer expert, has pointed the cancer causation gun squarely at an altered glucose metabolism. Bissell went back to the work of Otto Warburg to show us all just how deadly glucose can be in cancer. She has famously said, glucose metabolism in the presence of oxygen is not the consequence of the cancerous activity of malignant cells but is itself a cancerous event. Other researchers in neuroscience have pointed the smoking gun at the mitochondria in neuro-degeneration. These are diseases modern medicine has no answer for either. Could they be linked? Mitochondria are parts of our cell where food gets turned to electrons and water to protons. Mitochondria are basically small factories that normally pump out protons at a massive rate. These things do not happen in unison in brain tumor states. Within these protons is stored potential energy, and this potential energy is eventually transferred to water hydration shells around proteins and mitochondria throughout the entire cell. This potential energy is stored in the hydronium ion of the exclusion zone of water (EZ). The EZ is critical to cellular signaling in all life forms. When mitochondria make protons, water must be available to accept this energy package. If it is not, and mitochondria make too many protons, a positive charge builds up in and around the mitochondria because protons have a positive charge. A positive charge is acidic. This causes the local and surrounding pH to fall. This signal is read by the cell as rising inflammation, and the mitochondria response is to increase synthesis in ROS and/or RNS. These are the two signaling molecules that mitochondrial mainly use to ‘spread the word’ to other parts of the cell of how much ‘gasoline’ is in the gas tank to do cell work.
When that message gets muddled for any reason, we see problems develop at complex I of electron train transport chain (ECT). When failures occur here, an awful lot goes wrong in a cell. Most of this signaling chaos surrounding the basic mitochondrial information comes from literature on Parkinson’s disease or Alzheimer’s disease. These are diseases one gets before cancer usually develops but it shows the underlying problem at the mitochondrial and quantum level for all these diseases.
Volkow and Achermann both showed definitively that brain physiology is changed by up-regulating glucose metabolism with respect to non native EMF. Both of their studies are the best we have in reference to this specific issue in the published literature. Brain tumors have risen 500% over the last 50 years and no one seems to know why. Our third researcher, Bissell, a breast cancer expert, has pointed the cancer causation gun squarely at an altered glucose metabolism. Bissell went back to the work of Otto Warburg to show us all just how deadly glucose can be in cancer. She has famously said, glucose metabolism in the presence of oxygen is not the consequence of the cancerous activity of malignant cells but is itself a cancerous event. Other researchers in neuroscience have pointed the smoking gun at the mitochondria in neuro-degeneration. These are diseases modern medicine has no answer for either. Could they be linked? Mitochondria are parts of our cell where food gets turned to electrons and water to protons. Mitochondria are basically small factories that normally pump out protons at a massive rate. These things do not happen in unison in brain tumor states. Within these protons is stored potential energy, and this potential energy is eventually transferred to water hydration shells around proteins and mitochondria throughout the entire cell. This potential energy is stored in the hydronium ion of the exclusion zone of water (EZ). The EZ is critical to cellular signaling in all life forms. When mitochondria make protons, water must be available to accept this energy package. If it is not, and mitochondria make too many protons, a positive charge builds up in and around the mitochondria because protons have a positive charge. A positive charge is acidic. This causes the local and surrounding pH to fall. This signal is read by the cell as rising inflammation, and the mitochondria response is to increase synthesis in ROS and/or RNS. These are the two signaling molecules that mitochondrial mainly use to ‘spread the word’ to other parts of the cell of how much ‘gasoline’ is in the gas tank to do cell work.
When that message gets muddled for any reason, we see problems develop at complex I of electron train transport chain (ECT). When failures occur here, an awful lot goes wrong in a cell. Most of this signaling chaos surrounding the basic mitochondrial information comes from literature on Parkinson’s disease or Alzheimer’s disease. These are diseases one gets before cancer usually develops but it shows the underlying problem at the mitochondrial and quantum level for all these diseases.
What are the beacons of reproduction in humans?
The human placenta is under the control of two major hormones. Those two hormones are progesterone and leptin. Progesterone is pro-gestation. Leptin powers the energy to the placenta in pregnancy. The goal of the human placenta is simple. Its job is to steal the DHA, iodine, and Vitamin D stores in the pregnant women’s buttocks and hips where it is stored and it transfers it slowly over the 9 months to the infants forming neural circuits. This action depletes the woman’s stores as time elapses. If she starts off the journey depleted, the child’s brain will pay that toll in diminished neurologic function. A woman’s normal hip to waist ratio is ideally at 0.7. This too is controlled by optimal levels of DHA and the brain specific nutrients in her body. Her natural curves are present as an evolutionary signal to males that she is a good candidate for mating because she has the correct amount of brain-specific nutrients to make an optimal human brain. This is how evolution helps us select mates ideally using epigenetics. The hip to waist ratio in women is a key symbol to males that DHA is present in abundance, while inflammation is low, and her hormones are optimal to support gestation and successful reproduction of a progeny. Modern life, culture and socialization have destroyed many of these ancient evolutionary signals in our species. Women who are infertile usually are leptin resistant and do not have the correct hip to waist ratio because they are either lacking DHA or have too much omega 6 fat in their bodies to support placental function. In many of my educational consults, I explain to people that the goal of the human placenta in the mother is to “spin” the brain-specific nutrients into her child’s head from her body, just like it is her own gut’s job to spin the brain specific nutrients in her diet into her own head. The process in her gut parallels the placental physiology. It is controlled by the progesterone to estradiol ratio, inflammation, and leptin function. There is little difference from a biochemical standpoint. What many of them do not realize is that blocking the normal extremely low EMF fields by the combination of man-made EMFs has the same effect as a very poor diet. In many cases, this effect is far more dominant than just diet alone. All life is about energy. And when we lack it or can not transfer it properly to new cells of a new developing organism, neolithic diseases usually follow. This is how the brain and gut are tied to one another again by evolution. Form always follows function in life. It is human adaptation in the shortened gut that helped us able to encephalize from transitional apes as the diet and field our environment gave us changed. During human evolution there is nothing in the fossil record to make us think that an altered EMF signal was present. For the last 112 years however, there has been an abundance of evidence that the field has changed dramatically, while the food sourcing has also been altered by manufacturing and the food agra- complex and government interventions via regulation.
What does Vitamin D do?
1 Facilitates increased intestinal absorption of phosphorus and calcium as well as suppression of parathyroid hormone secretion to increase our plasma calcium concentrations. However, it does not dictate or direct where this calcium will be deposited in our bodies.
2 Levels above 50 ng/ml are associated with increased adiponectin levels. High adiponectin means you are less likely to be obese. So higher vitamin D levels can help us trim our fat stores. By decreasing fat levels, we can avoid the initial steps that lead to insulin resistance and eventually develop Type 2 Diabetes.
3 It’s a natural antibiotic that assists WBCs in clearing infections. It does this by stimulating immune cells to make a protein called cathelicidin. This protein is found on T cells, macrophages, neutrophils, and on our epithelial cells in our guts and respiratory system. It actually helps defend us from viruses and bacteria all the time when it is optimized. In our gut linings, it also activates the T regulator cells to protect the intestinal lining and the GALT that lies right behind the brush border. It now appears that low vitamin D status in the gut maybe a huge risk factor for the development of HIV general infection. Another major immune effect of Vitamin D is that is has the ability to block intracellular signals of NF Kappa beta and of TNF alpha. Both of these chemicals are part of the machinery that causes up-regulation of the stressful cellular response mechanisms in many pathological diseases such as cancer, autoimmunity and in obesity.
4 It is a direct inhibitor of the hormone renin in our kidneys and helps protect us from developing systemic systolic blood pressure elevation. It also protects the kidney directly from high levels of uric acid production that come from end stage fructose metabolism.
5 A single nucleotide polymorphism (SNP) has been linked to the development of early heart disease. This SNP is on the C allele of SNP # rs4646536 and is being studied in the NIH VITAL trial currently ongoing. This is a second mechanism to prevent heart disease but a more common one will be discussed below.
6 When the skin makes Vitamin D3 naturally, usually 10 - 20,000 IU are made locally in the skin. The excess Vitamin D3 is then broken down to its degradation products, which have been shown to inhibit the development of psoriasis in studies. These degradation products prevent the proliferation of the lower levels of the skin from reproducing at a faster rate than normal. This is the pathology found in psoriasis. The lower epidermis is known to grow 25 - 40 times faster, and the skin gets a large red plaque on its surface as a result. This is why light therapy is so effective in treating psoriasis. It’s kind of ironic that dermatologists don’t look at the pathological causes of this disease. Here, sunlight is curative because it stimulates Vitamin D3 production to make excess Vitamin D3 which then make degradation products. Anyone with psoriasis should have their Vitamin D levels checked and optimized before they do anything else. Most have extremely low levels and they tend to be obese and have higher cancer rates across the board.
7 In autoimmune diseases, we need to advocate much higher levels of Vitamin D. Why? In order for circulating vitamin D to perform its functions, it must first activate the vitamin D receptor (VDR). The problem is that many people with autoimmune disease have a genetic polymorphism that affects the expression and activation of the VDR and thus reduces the biological activity of vitamin D. Studies have shown that a significant number of patients with autoimmune diseases have several VDR polymorphisms. There are over 25 variants of VDR polymorphisms now known and the list grows monthly. If you have a VDR problem, you require much higher circulating levels of Vitamin D to bind to these defective receptors. As we have mentioned in multiple previous blogs, a leaky gut predisposes to the development of autoimmunity. Moreover, optimal Vitamin D levels are also linked to “tighter junctions” between the enterocytes of our intestinal lining making our guts “less leaky.” If the gut is less leaky, our immune system is stronger because it does not have to be activated constantly to protect the rest of the body. We have also seen above that vitamin D levels play a huge role in our immune surveillance in our GI tracts. It appears to be critical to push your levels to much higher plasma levels in these cases. I strongly recommend talking this over with your doctor. The fears of toxicity are very overblown in my estimation and the risk of too low a level for disease propagation is far too common and risky for your health. There is now very recent evidence out from Dr. Hector DeLuca about MS and autoimmune encephalitis. Dr. DeLuca believes that the degradation products of vitamin D3 and/or some byproducts of solar radiation confer health on us in some fashion. He says vitamin D3 degradation and sunlight is somehow active against a range of autoimmune illnesses. In his latest work, that “something” he is studying is active against an experimental model of multiple sclerosis. I have always felt that MS, ALS and Guillian Barre are tied in some fashion to vitamin D metabolism. It appears Dr. DeLuca believes this as well.
8 Vitamin D is a fat soluble molecule. It means you should take it with fat for absorption. But it also means that some people will not absorb it well at all. Who? Those with a leaky gut, people with IBD, Crohn’s, Ulcerative colitis, liver disease, those without a gallbladder, and those on a low fat diet that 99% of nutritionists and dietitians recommend. If you are a reader of this blog, you know I don’t advocate that stance at all. Who else has to worry? Those who have been on NSAIDs, steroids longer than a two weeks, those on blood thinners or anticoagulants, those on reflux medicines and antacids, and synthetic hormones such as birth control pills. Are you starting to understand now why we have an epidemic of hypo-vitaminosis of vitamin D?
9 Can you have a normal plasma D level and still have low vitamin D activity? Yes you can, and it is probably the biggest silent epidemic out there today. I most commonly see this in obese folks with hypothyroidism. 90% of the cases of hypothyroidism in the USA are cause by Hashimoto’s disease. This disease is an autoimmune disease and these patients universally have defective VDR receptors. That means they need very high levels of blood Vitamin D levels and optimization of their thyroid function to get results. Often, many obese people get stuck not losing weight because their doctors are fooled into thinking their thyroid and Vitamin D levels are fine. Most of the time, the levels are sub-therapeutic and patients find amazing results when their plasma levels are pushed a bit by the clinician. This is an area where you need to speak to your doctor. I often see this in post-op cancer patients, too, under extreme stress. Patients with high cortisol levels suffer the same fate.
10 Age will decrease your skin’s ability to make vitamin D3 from sunlight and cholesterol. As we go from age 20 to 60, we lose that ability by a four-fold magnitude. The darker our skin, the worse the conversion. So as we age, we need more sun or supplementation, not less of either. This is why so many older people see a higher incidence of neolithic diseases as well.
11 We as humans have a Vitamin D savings bank in our body. It is supported by a good protein diet and leads to a better Vitamin D level. An Epi-paleo diet is an optimal choice for this bank account. It works by making a protein called Vitamin D binding protein (DBP). It acts like albumin does in the blood. The vitamin D-binding protein (DBP) is a highly specific carrier for vitamin D and all of its metabolites found in the plasma. This allows us to store vast amounts of Vitamin D. Why do we need that from an evolutionary standpoint? Vitamin D synthesis from cholesterol by the sunlight is thus maintained within physiological limits estimated to be 0.01 to 2.5 mg of cholecalciferol per day. 2.5 mg per day translates to 100,000 IU per day! If we are protein deficient, we do not have this ability and our stores are low in low light levels. It not only protects our Vitamin D stores, but it also prevents the toxic effects of a high vitamin D level in the blood. Humans start to store Vitamin D3 when Vitamin 25(OH)D level is above 40 ng/ml. The interesting finding is that it is only around a level of 60 ng/ml that the stores are sufficient to see us through a winter with a resultant optimal D level. This is why dietary composition is critical for immunity. This information also shows why the flu season peaks in winter months in epidemiological studies. It also helps explain why those who are chronically ill or have serious diseases such as cancer have very weakened immune systems. This is why cancer patients have higher risks for developing multiple neolithic diseases as they age. Peripheral neuropathy and pain is one such example. Those with low HDL levels or frank liver disease tend to make the lowest amounts of DBP. This is true in hepatitis cases and in patients with metabolic syndrome as well. It also explains why other neolithic diseases afflict those people and why they all seemingly have low vitamin D levels, too. This is why we see an epidemic in the USA today. Before, we never looked for it, but now we are beginning to understand just how vital Vitamin D is for immunity and health.
12 In 2007, Richards found that higher vitamin D levels are also associated with longer telomere lengths. This means that optimal vitamin D levels reduce our cellular aging risk, reduce utilization of our stem cells, and decrease the leakiness of our mitochondria which drive the action of the telomerase enzyme that dictates telomere length. So it makes sense if your D level is low, your telomeres will be shortened and this, too, will put you at heightened risk for neolithic disease. All cellular systems seem to point to disease and increased aging with lower vitamin D levels. This is among one of the most congruent findings I have seen in biology since I began to review the biochemistry and literature in this area.
13 When you optimize your vitamin D3, you will notice your HDL will rise 10-30% in the first year. This signifies that the liver is doing a better job of “skimming” the portal circulation for endotoxins. This is the major mechanism that Vitamin D protects the heart, in my view. We all hear from doctors that a high HDL protects the heart. This is how: It makes the liver a master of defense. It also protects the brain from endotoxin assault, it reduces all causes of mental illness and it is a main defense in the brain gut axis. Read my VAP blog here to freshen up on this physiology.
14 Regarding cancer and Vitamin D3: The gene that codes for E-cadherin can be epigenetically silenced via promoter hypermethylation. This explains why Vitamin D3 cannot “prevent” or “cure” all cancers, since the E-caherin gene is under the direct regulation of Vitamin D3. Many people do not understand this on/off switch with regards to cancer.
15 Vitamin D Wrap Up So, I think I have just skimmed the surface here why Vitamin D does a ton more than I learned in medical school 20 years ago. I keep reading about it because we are finding out new things it does daily in organs such as the brain and nerves. Consider this: the ApoE4 allele is the allele that conferred the ability of humans to leave Africa and evolve and live in lower levels of solar radiation, yet still capture enough Vitamin D to survive. This allele is associated with other diseases these days, but it was ideally matched for humans who needed to migrate north and south from the equator for many reasons. It is also vitally important to our immunity and defense. New studies in 2009 showed that that Vitamin D also decreases the risk of breast cancer in women when their levels were over 50 ng/ml. This has huge implications for all women and all oncologists in my view.
2 Levels above 50 ng/ml are associated with increased adiponectin levels. High adiponectin means you are less likely to be obese. So higher vitamin D levels can help us trim our fat stores. By decreasing fat levels, we can avoid the initial steps that lead to insulin resistance and eventually develop Type 2 Diabetes.
3 It’s a natural antibiotic that assists WBCs in clearing infections. It does this by stimulating immune cells to make a protein called cathelicidin. This protein is found on T cells, macrophages, neutrophils, and on our epithelial cells in our guts and respiratory system. It actually helps defend us from viruses and bacteria all the time when it is optimized. In our gut linings, it also activates the T regulator cells to protect the intestinal lining and the GALT that lies right behind the brush border. It now appears that low vitamin D status in the gut maybe a huge risk factor for the development of HIV general infection. Another major immune effect of Vitamin D is that is has the ability to block intracellular signals of NF Kappa beta and of TNF alpha. Both of these chemicals are part of the machinery that causes up-regulation of the stressful cellular response mechanisms in many pathological diseases such as cancer, autoimmunity and in obesity.
4 It is a direct inhibitor of the hormone renin in our kidneys and helps protect us from developing systemic systolic blood pressure elevation. It also protects the kidney directly from high levels of uric acid production that come from end stage fructose metabolism.
5 A single nucleotide polymorphism (SNP) has been linked to the development of early heart disease. This SNP is on the C allele of SNP # rs4646536 and is being studied in the NIH VITAL trial currently ongoing. This is a second mechanism to prevent heart disease but a more common one will be discussed below.
6 When the skin makes Vitamin D3 naturally, usually 10 - 20,000 IU are made locally in the skin. The excess Vitamin D3 is then broken down to its degradation products, which have been shown to inhibit the development of psoriasis in studies. These degradation products prevent the proliferation of the lower levels of the skin from reproducing at a faster rate than normal. This is the pathology found in psoriasis. The lower epidermis is known to grow 25 - 40 times faster, and the skin gets a large red plaque on its surface as a result. This is why light therapy is so effective in treating psoriasis. It’s kind of ironic that dermatologists don’t look at the pathological causes of this disease. Here, sunlight is curative because it stimulates Vitamin D3 production to make excess Vitamin D3 which then make degradation products. Anyone with psoriasis should have their Vitamin D levels checked and optimized before they do anything else. Most have extremely low levels and they tend to be obese and have higher cancer rates across the board.
7 In autoimmune diseases, we need to advocate much higher levels of Vitamin D. Why? In order for circulating vitamin D to perform its functions, it must first activate the vitamin D receptor (VDR). The problem is that many people with autoimmune disease have a genetic polymorphism that affects the expression and activation of the VDR and thus reduces the biological activity of vitamin D. Studies have shown that a significant number of patients with autoimmune diseases have several VDR polymorphisms. There are over 25 variants of VDR polymorphisms now known and the list grows monthly. If you have a VDR problem, you require much higher circulating levels of Vitamin D to bind to these defective receptors. As we have mentioned in multiple previous blogs, a leaky gut predisposes to the development of autoimmunity. Moreover, optimal Vitamin D levels are also linked to “tighter junctions” between the enterocytes of our intestinal lining making our guts “less leaky.” If the gut is less leaky, our immune system is stronger because it does not have to be activated constantly to protect the rest of the body. We have also seen above that vitamin D levels play a huge role in our immune surveillance in our GI tracts. It appears to be critical to push your levels to much higher plasma levels in these cases. I strongly recommend talking this over with your doctor. The fears of toxicity are very overblown in my estimation and the risk of too low a level for disease propagation is far too common and risky for your health. There is now very recent evidence out from Dr. Hector DeLuca about MS and autoimmune encephalitis. Dr. DeLuca believes that the degradation products of vitamin D3 and/or some byproducts of solar radiation confer health on us in some fashion. He says vitamin D3 degradation and sunlight is somehow active against a range of autoimmune illnesses. In his latest work, that “something” he is studying is active against an experimental model of multiple sclerosis. I have always felt that MS, ALS and Guillian Barre are tied in some fashion to vitamin D metabolism. It appears Dr. DeLuca believes this as well.
8 Vitamin D is a fat soluble molecule. It means you should take it with fat for absorption. But it also means that some people will not absorb it well at all. Who? Those with a leaky gut, people with IBD, Crohn’s, Ulcerative colitis, liver disease, those without a gallbladder, and those on a low fat diet that 99% of nutritionists and dietitians recommend. If you are a reader of this blog, you know I don’t advocate that stance at all. Who else has to worry? Those who have been on NSAIDs, steroids longer than a two weeks, those on blood thinners or anticoagulants, those on reflux medicines and antacids, and synthetic hormones such as birth control pills. Are you starting to understand now why we have an epidemic of hypo-vitaminosis of vitamin D?
9 Can you have a normal plasma D level and still have low vitamin D activity? Yes you can, and it is probably the biggest silent epidemic out there today. I most commonly see this in obese folks with hypothyroidism. 90% of the cases of hypothyroidism in the USA are cause by Hashimoto’s disease. This disease is an autoimmune disease and these patients universally have defective VDR receptors. That means they need very high levels of blood Vitamin D levels and optimization of their thyroid function to get results. Often, many obese people get stuck not losing weight because their doctors are fooled into thinking their thyroid and Vitamin D levels are fine. Most of the time, the levels are sub-therapeutic and patients find amazing results when their plasma levels are pushed a bit by the clinician. This is an area where you need to speak to your doctor. I often see this in post-op cancer patients, too, under extreme stress. Patients with high cortisol levels suffer the same fate.
10 Age will decrease your skin’s ability to make vitamin D3 from sunlight and cholesterol. As we go from age 20 to 60, we lose that ability by a four-fold magnitude. The darker our skin, the worse the conversion. So as we age, we need more sun or supplementation, not less of either. This is why so many older people see a higher incidence of neolithic diseases as well.
11 We as humans have a Vitamin D savings bank in our body. It is supported by a good protein diet and leads to a better Vitamin D level. An Epi-paleo diet is an optimal choice for this bank account. It works by making a protein called Vitamin D binding protein (DBP). It acts like albumin does in the blood. The vitamin D-binding protein (DBP) is a highly specific carrier for vitamin D and all of its metabolites found in the plasma. This allows us to store vast amounts of Vitamin D. Why do we need that from an evolutionary standpoint? Vitamin D synthesis from cholesterol by the sunlight is thus maintained within physiological limits estimated to be 0.01 to 2.5 mg of cholecalciferol per day. 2.5 mg per day translates to 100,000 IU per day! If we are protein deficient, we do not have this ability and our stores are low in low light levels. It not only protects our Vitamin D stores, but it also prevents the toxic effects of a high vitamin D level in the blood. Humans start to store Vitamin D3 when Vitamin 25(OH)D level is above 40 ng/ml. The interesting finding is that it is only around a level of 60 ng/ml that the stores are sufficient to see us through a winter with a resultant optimal D level. This is why dietary composition is critical for immunity. This information also shows why the flu season peaks in winter months in epidemiological studies. It also helps explain why those who are chronically ill or have serious diseases such as cancer have very weakened immune systems. This is why cancer patients have higher risks for developing multiple neolithic diseases as they age. Peripheral neuropathy and pain is one such example. Those with low HDL levels or frank liver disease tend to make the lowest amounts of DBP. This is true in hepatitis cases and in patients with metabolic syndrome as well. It also explains why other neolithic diseases afflict those people and why they all seemingly have low vitamin D levels, too. This is why we see an epidemic in the USA today. Before, we never looked for it, but now we are beginning to understand just how vital Vitamin D is for immunity and health.
12 In 2007, Richards found that higher vitamin D levels are also associated with longer telomere lengths. This means that optimal vitamin D levels reduce our cellular aging risk, reduce utilization of our stem cells, and decrease the leakiness of our mitochondria which drive the action of the telomerase enzyme that dictates telomere length. So it makes sense if your D level is low, your telomeres will be shortened and this, too, will put you at heightened risk for neolithic disease. All cellular systems seem to point to disease and increased aging with lower vitamin D levels. This is among one of the most congruent findings I have seen in biology since I began to review the biochemistry and literature in this area.
13 When you optimize your vitamin D3, you will notice your HDL will rise 10-30% in the first year. This signifies that the liver is doing a better job of “skimming” the portal circulation for endotoxins. This is the major mechanism that Vitamin D protects the heart, in my view. We all hear from doctors that a high HDL protects the heart. This is how: It makes the liver a master of defense. It also protects the brain from endotoxin assault, it reduces all causes of mental illness and it is a main defense in the brain gut axis. Read my VAP blog here to freshen up on this physiology.
14 Regarding cancer and Vitamin D3: The gene that codes for E-cadherin can be epigenetically silenced via promoter hypermethylation. This explains why Vitamin D3 cannot “prevent” or “cure” all cancers, since the E-caherin gene is under the direct regulation of Vitamin D3. Many people do not understand this on/off switch with regards to cancer.
15 Vitamin D Wrap Up So, I think I have just skimmed the surface here why Vitamin D does a ton more than I learned in medical school 20 years ago. I keep reading about it because we are finding out new things it does daily in organs such as the brain and nerves. Consider this: the ApoE4 allele is the allele that conferred the ability of humans to leave Africa and evolve and live in lower levels of solar radiation, yet still capture enough Vitamin D to survive. This allele is associated with other diseases these days, but it was ideally matched for humans who needed to migrate north and south from the equator for many reasons. It is also vitally important to our immunity and defense. New studies in 2009 showed that that Vitamin D also decreases the risk of breast cancer in women when their levels were over 50 ng/ml. This has huge implications for all women and all oncologists in my view.
Why we get cancer?
I believe heart disease and inflammatory bowel diseases are pre-cancerous states. I also believe autoimmunity is a precancerous state. I believe autoimmunity and cancer are just steps apart. I also believe we will soon find that these diseases are linked to an altered environment and circadian signaling. Epidemiological studies link all these disease to inflammation generation. The pathway in humans tied to inflammation is the NRF2 pathway. Most people and doctors already know there are links to inflammation but they are not sure how they link to circadian mismatches. But what is less talked about is how this all fits biologically. Today we are going to begin to tackle this. I think two critical co-variables need to be looked at in detail and are found in our immune system physiology. Those two critical factors are Vitamin D status and Selenium status. I have already shared with you how a leaky gut is tied to autoimmunity in some detail in my recent blog. Today we are going to begin to tie three levels together, oncogenesis, immunity, and the brain gut axis. In June 2010, the American Journal of Pathology published a study that caught my eye. It reviewed at the Vitamin D Receptor (VDR) and the generation of inflammation in the large intestine in a mice model. The paper looked at gut inflammation in the presence of a Salmonella infection. Salmonella is a bacterial infection. Mice which lacked VDRs, seemed to have higher states of gut inflammation and worse outcomes than control groups. The key difference however was the high levels of IL-6, an inflammatory cytokine. IL-6 is tied directly to the NrF2 pathway. IL-6 is a bad actor in cellular homeostasis and in circadian signaling. It is seen in most cancers and all inflammatory conditions in humans to some degree. Most gut absorption is done via the transcellular pathway (90% through gut cells). The remainder of gut transport occurs via intracellular methods (tight gut junctions) that are controlled by vitamin D status. The less Vitamin D you have, the more leaky your tight junctions will be, and this exposes your immune system to direct assault. This assault is then aimed directly at our liver for detoxification. And our liver has to defend the rest of our body from inflammatory cytokines.
The key finding in the article was that animals with an intact VDR faced less gut inflammation and had lower rates of Salmonella infection. The VDR mechanism of action is to block the signal transduction of NF-Kb (911 signal of the cell also from the nrf2 pathway) from the cell membrane to the nucleus of the cell. Once it gets into the nucleus, it binds to our DNA to promote many inflammatory pathways that lead to more cytokine production. One pathway leads to IL-1b production seen in all autoimmune conditions. The other pathway leads to IL-6 and TNF alpha generation that alter the promotor region of p53 gene (protector gene of our entire genome) by hypomethylation and allows for cellular oncogenesis if the “switch” stays on long enough. VDR up-regulates a protein called lkB which won’t allow the NF-k beta to enter the nucleus of the cell to set the plan of oncogenesis to commence action. It also appears that the VDR does not even require active vitamin D3 to be present for this to occur.
In 2002, in a study by Al-Tate et al, we learned about how Selenium (Se) affects gut inflammation and generation of autoimmunity and oncogenesis. 50% of plasma Selenium is contained in human glycoprotein selenoprotein P (SeP) and is highly expressed in the human gut, specifically in the liver (gut protector). In times of high inflammation from the gut, its expression is DOWN-regulated by various inflammatory cytokines. Selenium is found in seafood in high quantities. IL-1b is the most potent to do this followed by TNF- beta and interferon gamma. It appears that development of autoimmune diseases is the cellular choice if IL-1 is predominantly generated, and cancer of various gut organs are favored if other inflammatory cytokines are generated chronically. For autoimmune conditions, this cytokine pathway is altered in the microglia cells of the brain. This affects how the MHC 1 gene is expressed epigenetically. The very interesting fact is that, with an adenoma (beginning of tumors in the colon that are initially benign) presence in the colon, there was a strong association with decreasing SeP. Patients with Se levels below 70 mcg/L are at the highest risk for oncogenesis(Psathakis et al 1998). People who eat a standard American diet as advocated by the USDA carry that risk. Selenium also allows us to generate a stable pipeline of methylated metabolites that directly protects our DNA, and specifically the p53 gene. It really up-regulates the production of mono-methylated species and has amazing chemotherapeutic potential. These are rarely used in conventional chemotherapy. Remember that most methyl transfers occur in humans from mainly the B vitamins. B12 is most mentioned. It only comes from animal proteins and those of you who advocate the vegetarian method of eating all have to supplement B12 for this very reason. B12 is very abundant in seafood. In fact, B vitamins are very common in the marine food chain. It is found nowhere else but in fish/animal protein and fat. So now you are starting to realize why being a vegetarian leads can lead to a higher oncogenic incidence, higher autoimmune disease risk, along with higher Crohn’s disease, heart disease and diabetes risk!
To further illustrate how important methyl transfers are, I suggest a trip East. Just go to southern India to see what a life-long vegetarian diet does to a human body. The epidemiology data out of India is just staggering with regards to these neolithic diseases. The southern region of India is filled with mostly vegetarian sects, while the Northern territories are more into animal protein diets. There is also more new modern technology industry found in southern India which further alters the field that biology has to act in. It should be required of every person who thinks this is the “moral” way to eat. If it kills and hurts humans, how humane can it really be from the moral standpoint? I think it guarantees you a suboptimal life if you choose it. Enough of that PSA now. The amount of industrialization has been massive over the last 40 years in this region of India. They have also ramped up their use of artificial light and modern technology.
Cancer prediction The good news is that many of the 6 million people being treated for cancer today will go on to live a full life. The numbers of those who do survive in my opinion are still far too low (about 45-50%). Moreover, many of the close to 2,000 cancers deaths that occur daily happen because the victims’ families were completely unaware of the depth of resources currently available to treat cancer conventionally and with alternatives such as complementary or integrative therapies.
Once diagnosed with this disease, you get shaken to your core. It is imperative that you know that this disease cannot only be fought but it can be prevented if you decide to immediately alter some of the things you do and lose some of the dogma you have accumulated in your life. This is especially true if you are in the healthcare field and have lived in dogma your whole adult life. This book is written by a physician researcher who not only got hit with the cancer diagnosis but got hit with a brain cancer that is exceptionally deadly. He was able to deconstruct his own beliefs as a physician with new science that was around to researchers but not well known by his oncologists. This book is a must for anyone with cancer or who has risk factors present so you can beat it before it begins. This is honestly one of the reasons I wrote my QUILT because I believe if you protect your cells you will never get this disease. Now that a friend has it…here is a post directed at what you may consider doing right away after consulting with your oncologist. Consider consulting a major cancer center such as MD Anderson for a second opinion.
1. Read the book Anticancer mentioned above. It’s critical to you seeing this disease in a new light.
2. Immediately alter your diet to the Epi-paleo Rx and away from a Standard Western Diet.
3. Begin a meditation scheme as soon as possible to control your cortisol and anxiety. (Choice is unimportant but doing it is life saving)
4. The patient should consult the protocols entitled Cancer Treatment: The critical Factors in Cancer: Should patients take dietary supplements for the type of cancer you have?
5. Consider beginning a supplement regime to include Curcumin, Reservatrol, Quercetin, Omega three Fish oil (Rx grade), Vitamin D3 with a target of being over 50 ng/dl, liberal use of CoEnZQ10 daily, R-alpha lipoic acid and a vitamin K supplement daily. Consider use of N Acetyl Cysteine daily as well. Notice I did not put the dosages down because the doses required for anti-cancer therapy are significantly higher than one would use in a preventative state. This should be done with consultation of your oncologist. If your oncologist is not open minded about these issues…after reading the book in step one you might need to find a new oncologist. These are what I consider to be the core supplements to most cancers that humans get.
6. Within your diet, always added turmeric, ginger, garlic, rosemary and basil to your foods as much as possible. You should drink 1 liter of green tea per day. Green tea contains L -Theanine which decreases anxiety but is an adjunct to chemotherapeutic drugs by making them more effective . You can also use green tea extracts if you don’t want to drink this much fluid or you can’t because of your condition.
7. In 1955, Nobel Laureate Otto Warburg found that all cancers use glucose for energy substrate and that high levels of insulin also allow the body to lose control of the immune system that will defend it. This means the patient has to limit anything that stimulates insulin. A strict low-carb Epi-paleo template does just this. A good reference for the diet is here.
8. Your immune system is your best defense against your cancer. Optimize your vitamin D levels and keep your insulin levels below two. Lowering your cortisol levels optimizes leptin but most importantly up-regulates your Natural Killer cells (WBC’s) that are part of your cell-mediated immune system that actively fights cancer. You will read a ton about these cells in the book I recommended in step one.
9. Veggies. Make cruciferous veggies a staple. All plants of the Brassica plants are your friends. Glucosinolates can inhibit, retard, and reverse experimental multistage oncogenesis. The reason is the release of isothiocyanantes such as sulphoraphanes. Sulphoraphanes do two main things. They promote apoptosis (levels 19) and they induce phase two detoxification enzymes in the liver that strengthen the p53 gene as the guardian of our genomes. Necrosis of cancer cells is commonly seen when they are exposed to sulphoraphanes consistently over time. Broccoli also includes a secondary metabolite called Indole 3 Carbinol that further breaks down to another anti-cancer chemical called DIM, diindolylmethane. You can’t eat enough of these veggies if you have cancer in my view. I3C also blocks 16 -hydroxyestrone and is quite helpful in preventing breast and ovarian cancers in women and prostate cancer in men.
10. Here is the counterintuitive one to the dogma you have had drummed into your head… eat tons of cholesterol. Especially coconut oil. Many epidemiological studies have shown that lower levels of serum cholesterol correlate with higher cancer rates. This is why eating a ketogenic Epi-paleo diet makes a ton of sense. Why a ketogenic diet? Because all cancers utilize glucose for substrate. You need to change the cellular fuel of choice. Go Google Otto Warburg for more details. Ketogenic diets should be loaded with MCT from coconut oils as they confer huge advantages to normal cells over cancer cells. This leg-up allows your immune system to catch up to the cancerous cells and destroy them using your own biological machinery. There are numerous cancer journal articles published that show the same links.
Dedicated to Mary. Never submit and conquer it with your defenses. They are your best weapon in this fight no matter what any physician tells you. Optimize them and you will win this battl
The key finding in the article was that animals with an intact VDR faced less gut inflammation and had lower rates of Salmonella infection. The VDR mechanism of action is to block the signal transduction of NF-Kb (911 signal of the cell also from the nrf2 pathway) from the cell membrane to the nucleus of the cell. Once it gets into the nucleus, it binds to our DNA to promote many inflammatory pathways that lead to more cytokine production. One pathway leads to IL-1b production seen in all autoimmune conditions. The other pathway leads to IL-6 and TNF alpha generation that alter the promotor region of p53 gene (protector gene of our entire genome) by hypomethylation and allows for cellular oncogenesis if the “switch” stays on long enough. VDR up-regulates a protein called lkB which won’t allow the NF-k beta to enter the nucleus of the cell to set the plan of oncogenesis to commence action. It also appears that the VDR does not even require active vitamin D3 to be present for this to occur.
In 2002, in a study by Al-Tate et al, we learned about how Selenium (Se) affects gut inflammation and generation of autoimmunity and oncogenesis. 50% of plasma Selenium is contained in human glycoprotein selenoprotein P (SeP) and is highly expressed in the human gut, specifically in the liver (gut protector). In times of high inflammation from the gut, its expression is DOWN-regulated by various inflammatory cytokines. Selenium is found in seafood in high quantities. IL-1b is the most potent to do this followed by TNF- beta and interferon gamma. It appears that development of autoimmune diseases is the cellular choice if IL-1 is predominantly generated, and cancer of various gut organs are favored if other inflammatory cytokines are generated chronically. For autoimmune conditions, this cytokine pathway is altered in the microglia cells of the brain. This affects how the MHC 1 gene is expressed epigenetically. The very interesting fact is that, with an adenoma (beginning of tumors in the colon that are initially benign) presence in the colon, there was a strong association with decreasing SeP. Patients with Se levels below 70 mcg/L are at the highest risk for oncogenesis(Psathakis et al 1998). People who eat a standard American diet as advocated by the USDA carry that risk. Selenium also allows us to generate a stable pipeline of methylated metabolites that directly protects our DNA, and specifically the p53 gene. It really up-regulates the production of mono-methylated species and has amazing chemotherapeutic potential. These are rarely used in conventional chemotherapy. Remember that most methyl transfers occur in humans from mainly the B vitamins. B12 is most mentioned. It only comes from animal proteins and those of you who advocate the vegetarian method of eating all have to supplement B12 for this very reason. B12 is very abundant in seafood. In fact, B vitamins are very common in the marine food chain. It is found nowhere else but in fish/animal protein and fat. So now you are starting to realize why being a vegetarian leads can lead to a higher oncogenic incidence, higher autoimmune disease risk, along with higher Crohn’s disease, heart disease and diabetes risk!
To further illustrate how important methyl transfers are, I suggest a trip East. Just go to southern India to see what a life-long vegetarian diet does to a human body. The epidemiology data out of India is just staggering with regards to these neolithic diseases. The southern region of India is filled with mostly vegetarian sects, while the Northern territories are more into animal protein diets. There is also more new modern technology industry found in southern India which further alters the field that biology has to act in. It should be required of every person who thinks this is the “moral” way to eat. If it kills and hurts humans, how humane can it really be from the moral standpoint? I think it guarantees you a suboptimal life if you choose it. Enough of that PSA now. The amount of industrialization has been massive over the last 40 years in this region of India. They have also ramped up their use of artificial light and modern technology.
Cancer prediction The good news is that many of the 6 million people being treated for cancer today will go on to live a full life. The numbers of those who do survive in my opinion are still far too low (about 45-50%). Moreover, many of the close to 2,000 cancers deaths that occur daily happen because the victims’ families were completely unaware of the depth of resources currently available to treat cancer conventionally and with alternatives such as complementary or integrative therapies.
Once diagnosed with this disease, you get shaken to your core. It is imperative that you know that this disease cannot only be fought but it can be prevented if you decide to immediately alter some of the things you do and lose some of the dogma you have accumulated in your life. This is especially true if you are in the healthcare field and have lived in dogma your whole adult life. This book is written by a physician researcher who not only got hit with the cancer diagnosis but got hit with a brain cancer that is exceptionally deadly. He was able to deconstruct his own beliefs as a physician with new science that was around to researchers but not well known by his oncologists. This book is a must for anyone with cancer or who has risk factors present so you can beat it before it begins. This is honestly one of the reasons I wrote my QUILT because I believe if you protect your cells you will never get this disease. Now that a friend has it…here is a post directed at what you may consider doing right away after consulting with your oncologist. Consider consulting a major cancer center such as MD Anderson for a second opinion.
1. Read the book Anticancer mentioned above. It’s critical to you seeing this disease in a new light.
2. Immediately alter your diet to the Epi-paleo Rx and away from a Standard Western Diet.
3. Begin a meditation scheme as soon as possible to control your cortisol and anxiety. (Choice is unimportant but doing it is life saving)
4. The patient should consult the protocols entitled Cancer Treatment: The critical Factors in Cancer: Should patients take dietary supplements for the type of cancer you have?
5. Consider beginning a supplement regime to include Curcumin, Reservatrol, Quercetin, Omega three Fish oil (Rx grade), Vitamin D3 with a target of being over 50 ng/dl, liberal use of CoEnZQ10 daily, R-alpha lipoic acid and a vitamin K supplement daily. Consider use of N Acetyl Cysteine daily as well. Notice I did not put the dosages down because the doses required for anti-cancer therapy are significantly higher than one would use in a preventative state. This should be done with consultation of your oncologist. If your oncologist is not open minded about these issues…after reading the book in step one you might need to find a new oncologist. These are what I consider to be the core supplements to most cancers that humans get.
6. Within your diet, always added turmeric, ginger, garlic, rosemary and basil to your foods as much as possible. You should drink 1 liter of green tea per day. Green tea contains L -Theanine which decreases anxiety but is an adjunct to chemotherapeutic drugs by making them more effective . You can also use green tea extracts if you don’t want to drink this much fluid or you can’t because of your condition.
7. In 1955, Nobel Laureate Otto Warburg found that all cancers use glucose for energy substrate and that high levels of insulin also allow the body to lose control of the immune system that will defend it. This means the patient has to limit anything that stimulates insulin. A strict low-carb Epi-paleo template does just this. A good reference for the diet is here.
8. Your immune system is your best defense against your cancer. Optimize your vitamin D levels and keep your insulin levels below two. Lowering your cortisol levels optimizes leptin but most importantly up-regulates your Natural Killer cells (WBC’s) that are part of your cell-mediated immune system that actively fights cancer. You will read a ton about these cells in the book I recommended in step one.
9. Veggies. Make cruciferous veggies a staple. All plants of the Brassica plants are your friends. Glucosinolates can inhibit, retard, and reverse experimental multistage oncogenesis. The reason is the release of isothiocyanantes such as sulphoraphanes. Sulphoraphanes do two main things. They promote apoptosis (levels 19) and they induce phase two detoxification enzymes in the liver that strengthen the p53 gene as the guardian of our genomes. Necrosis of cancer cells is commonly seen when they are exposed to sulphoraphanes consistently over time. Broccoli also includes a secondary metabolite called Indole 3 Carbinol that further breaks down to another anti-cancer chemical called DIM, diindolylmethane. You can’t eat enough of these veggies if you have cancer in my view. I3C also blocks 16 -hydroxyestrone and is quite helpful in preventing breast and ovarian cancers in women and prostate cancer in men.
10. Here is the counterintuitive one to the dogma you have had drummed into your head… eat tons of cholesterol. Especially coconut oil. Many epidemiological studies have shown that lower levels of serum cholesterol correlate with higher cancer rates. This is why eating a ketogenic Epi-paleo diet makes a ton of sense. Why a ketogenic diet? Because all cancers utilize glucose for substrate. You need to change the cellular fuel of choice. Go Google Otto Warburg for more details. Ketogenic diets should be loaded with MCT from coconut oils as they confer huge advantages to normal cells over cancer cells. This leg-up allows your immune system to catch up to the cancerous cells and destroy them using your own biological machinery. There are numerous cancer journal articles published that show the same links.
Dedicated to Mary. Never submit and conquer it with your defenses. They are your best weapon in this fight no matter what any physician tells you. Optimize them and you will win this battl
How do you improve your REDOX potential? Part 2
A constant source of high-quality marine/animal protein is needed to maintain your redox potential. The quality of the collagen in your body is directly tied to your redox potential. When your redox potential is low, protein is scheduled for excessive turnover by the ubiquination system. This is energy intensive to the cell. If you have torn tendons or meniscus in your body, these are symptoms tied to a poor redox potential. Collagen is the “electric wire” embedded in your intracellular and extracellular water that conducts piezoelectric signals all over your body. Water is life’s battery, collagen is the wire that connects the negative and positive charge within the battery, and the sun’s light is the constant energy source for the water battery to recharge.
If your redox level is low you should avoid all alcohol no matter what. You should also avoid black and red tea and salt because both are loaded with fluoride salts. F- reduces the ability to transmit electric signals in both water and collagen. You also should avoid all chewing tobacco for the same reason. Dip tobacco is loaded with halogens and transition metals that act to reduce your redox potential. You can use N-Acteyl cysteine supplementation to help. Use reverse osmosis water, spring water, or mineral water for your drinking water consistently. Avoid all fluoride products, drugs and pesticides. Read labels. Avoid grains because they are loaded with brominated chemicals. Bromine is a halogen-like fluoride. You can use activated charcoal to clear water of bromine and chlorine, but not fluoride. To remove fluoride from drinking water, you will need activated alumina defluoridation filters. They have to be replaced after a few days of use. Do not boil your water if it is fluoridated because it raises the F- level in the water. Soaking in warm water with F- also concentrates the effect. Avoid any exogenous salts in your drinking water if you can. This is not an axiomatic rule. Why? In addition to metals, salts can also conduct electricity. In cells, we do not want a salt disturbing semiconducting flow of electrons. This creates loss of efficiency for energy transfers because it creates a smaller exclusion zone in water in a cell. In salt electric conduction, there are no free electrons moving, so the conductivity depends on the specific ions used in the salt. When a salt is in water, it is either melting or dissolving, so that the ions of the salt are free to move to conduct the current. Their atomic sizes however limit coherent conduction with 100% efficiency that is seen in a semiconductor. K+ is the key element in life’s equation with water to create a semiconductor that has the same properties we see in topologic insulators. Consider a Magnetico sleep pad if you can afford it. The more non-native EMF you have in your life, the more the pad becomes a helper to your wellness. However, only sleep on it when it is dim or dark outside. The reason is you must create a marked difference between night and daytime magnetic sense to your body since most of our planet is now affected by atmospheric EMF that drowns out the native magnetic field effect. This is a way to teach the brain there still is a difference between night and day.
Be barefoot as much as possible when walking upon earth or concrete. Grounding shoes are a great option for diabetics who worry about their foot health and want to avoid cuts.
Physiologic ketosis improves your redox potential as well. Ketosis is a state of elevated levels of ketone bodies in the body. It means our bodies are using fat for energy. The reason it improves redox potention is because ketosis increases your NAD+ level. NAD+ and SIRT 6 are linked in very key ways. SIRT 6 has two roles based on its two functions. They are deacetylation of histones and mono-ADP ribosylation of PARP1 proteins on Histone 3 subunits. In addition, SIRT 6 puts multiple mono-ADP-ribosyl groups on the DNA repair protein, PARP1, which also repairs DNA in response to oxidative stress. Unfortunately, all of this DNA repair by PARP1 uses up NAD+, which leaves the cell’s nuclear levels of NAD+.
As a result, all of the SIRT1 proteins cannot work since they all need NAD+ as a cofactor for enzyme action. Thus, the dual role of SIRT6 in both telomeric silencing and DNA repair is believed to be a root issue associated with aging. This is why those with a chronically low redox potential should always consider ketosis. Sirt 6 is linked to ketosis, cold, telomere length, and longevity.
Lowering stress is a great way to improve your redox potential. The use of biofeedback, neural feedback, message, yoga, Pilates, music, dance, walking, visualization and meditation of all types help improve your redox potential. Make these staples in your lifestyle if you have evidence of a low redox potential. Avoid all unnecessary non-native EMFs. This includes all blue tooth devices. The higher the “G level of the network or the device,” the worse it is for you to use. These environments lower your redox potential because you are leaking electrons from your tissues to the environment and you can not see it.
If your redox level is low you should avoid all alcohol no matter what. You should also avoid black and red tea and salt because both are loaded with fluoride salts. F- reduces the ability to transmit electric signals in both water and collagen. You also should avoid all chewing tobacco for the same reason. Dip tobacco is loaded with halogens and transition metals that act to reduce your redox potential. You can use N-Acteyl cysteine supplementation to help. Use reverse osmosis water, spring water, or mineral water for your drinking water consistently. Avoid all fluoride products, drugs and pesticides. Read labels. Avoid grains because they are loaded with brominated chemicals. Bromine is a halogen-like fluoride. You can use activated charcoal to clear water of bromine and chlorine, but not fluoride. To remove fluoride from drinking water, you will need activated alumina defluoridation filters. They have to be replaced after a few days of use. Do not boil your water if it is fluoridated because it raises the F- level in the water. Soaking in warm water with F- also concentrates the effect. Avoid any exogenous salts in your drinking water if you can. This is not an axiomatic rule. Why? In addition to metals, salts can also conduct electricity. In cells, we do not want a salt disturbing semiconducting flow of electrons. This creates loss of efficiency for energy transfers because it creates a smaller exclusion zone in water in a cell. In salt electric conduction, there are no free electrons moving, so the conductivity depends on the specific ions used in the salt. When a salt is in water, it is either melting or dissolving, so that the ions of the salt are free to move to conduct the current. Their atomic sizes however limit coherent conduction with 100% efficiency that is seen in a semiconductor. K+ is the key element in life’s equation with water to create a semiconductor that has the same properties we see in topologic insulators. Consider a Magnetico sleep pad if you can afford it. The more non-native EMF you have in your life, the more the pad becomes a helper to your wellness. However, only sleep on it when it is dim or dark outside. The reason is you must create a marked difference between night and daytime magnetic sense to your body since most of our planet is now affected by atmospheric EMF that drowns out the native magnetic field effect. This is a way to teach the brain there still is a difference between night and day.
Be barefoot as much as possible when walking upon earth or concrete. Grounding shoes are a great option for diabetics who worry about their foot health and want to avoid cuts.
Physiologic ketosis improves your redox potential as well. Ketosis is a state of elevated levels of ketone bodies in the body. It means our bodies are using fat for energy. The reason it improves redox potention is because ketosis increases your NAD+ level. NAD+ and SIRT 6 are linked in very key ways. SIRT 6 has two roles based on its two functions. They are deacetylation of histones and mono-ADP ribosylation of PARP1 proteins on Histone 3 subunits. In addition, SIRT 6 puts multiple mono-ADP-ribosyl groups on the DNA repair protein, PARP1, which also repairs DNA in response to oxidative stress. Unfortunately, all of this DNA repair by PARP1 uses up NAD+, which leaves the cell’s nuclear levels of NAD+.
As a result, all of the SIRT1 proteins cannot work since they all need NAD+ as a cofactor for enzyme action. Thus, the dual role of SIRT6 in both telomeric silencing and DNA repair is believed to be a root issue associated with aging. This is why those with a chronically low redox potential should always consider ketosis. Sirt 6 is linked to ketosis, cold, telomere length, and longevity.
Lowering stress is a great way to improve your redox potential. The use of biofeedback, neural feedback, message, yoga, Pilates, music, dance, walking, visualization and meditation of all types help improve your redox potential. Make these staples in your lifestyle if you have evidence of a low redox potential. Avoid all unnecessary non-native EMFs. This includes all blue tooth devices. The higher the “G level of the network or the device,” the worse it is for you to use. These environments lower your redox potential because you are leaking electrons from your tissues to the environment and you can not see it.
How do you improve your REDOX potential? Part 1
Pay attention to sunsets and dim light at night. Though light was known to influence the circadian mechanism via melanopsin, according to the literature, its effects on non-circadian processes were considered minor from 2005 to 2013.
That is now changing, especially when you understand how dim light really works in the brain. It has been recently shown in mammals that when melanopsin signaling is altered in the CNS for any reason at all, mammals lose the ability to catch up on sleep permanently. As they lose the ability to sleep, they simultaneously lose autographic efficiency and their regenerative potential for all tissues, and they lose the ability to tap into Becker’s DC current.
When you lose the DC current, it means your redox potential is bad. This is why a lack of sleep often leads to disease and an early death. Over time, these organisms will lose their memory and they will gain more fat mass as this alteration of melanopsin continues. There are several additional useful biomarkers for identifying patients in whom glutathione is low. One such indicator is elevated Gamma glutamyltransferase (GGT), the enzyme that breaks down glutathione from the blood to allow its importation into the cells. Up-regulation of GGT has been observed in cells deficient in glutathione.
Cold Thermogenesis improves your redox potential because it improves the flow of electrons on the surface of water and proteins without any energy costs. It also increases the density of water, allowing the water to carry more O2 to your cells.
The second effect is has on water is that it “expands the exclusion zone (EZ) of water” and more O2 can then be dissolved in plasma because water density rises. As these physical process happen, eNOS rises within blood vessels to cause vasodilation. A larger EZ also improves blood flow because it makes more protons from water to augment flow and reduces pressures in the heart.
Summer sunlight can grow the EZ layer in water by a different mechanism, because of the infrared spectrum that is present in sunlight during this season. The mechanism is different but the results on water chemistry are exactly the same. Both actions increase the Exclusion Zone (EZ) and by definition, increase the redox potential of water. This allows enzymatic reaction rates to happen at the speed of light or close to it. (Mae Wan Ho video alert.) If you live in a low-light situation or it is winter time, consider using a hot spring, volcanic bath house or a hot tub to augment your EZ by using the heat of each one to create a large EZ in your cells, which I describe next. The Fournier effect using warm and cold water is a great way to recharge a low redox potential. It uses heat and cold simultaneously to alter interfascial water in your cells to increase the EZ of water.
That is now changing, especially when you understand how dim light really works in the brain. It has been recently shown in mammals that when melanopsin signaling is altered in the CNS for any reason at all, mammals lose the ability to catch up on sleep permanently. As they lose the ability to sleep, they simultaneously lose autographic efficiency and their regenerative potential for all tissues, and they lose the ability to tap into Becker’s DC current.
When you lose the DC current, it means your redox potential is bad. This is why a lack of sleep often leads to disease and an early death. Over time, these organisms will lose their memory and they will gain more fat mass as this alteration of melanopsin continues. There are several additional useful biomarkers for identifying patients in whom glutathione is low. One such indicator is elevated Gamma glutamyltransferase (GGT), the enzyme that breaks down glutathione from the blood to allow its importation into the cells. Up-regulation of GGT has been observed in cells deficient in glutathione.
Cold Thermogenesis improves your redox potential because it improves the flow of electrons on the surface of water and proteins without any energy costs. It also increases the density of water, allowing the water to carry more O2 to your cells.
The second effect is has on water is that it “expands the exclusion zone (EZ) of water” and more O2 can then be dissolved in plasma because water density rises. As these physical process happen, eNOS rises within blood vessels to cause vasodilation. A larger EZ also improves blood flow because it makes more protons from water to augment flow and reduces pressures in the heart.
Summer sunlight can grow the EZ layer in water by a different mechanism, because of the infrared spectrum that is present in sunlight during this season. The mechanism is different but the results on water chemistry are exactly the same. Both actions increase the Exclusion Zone (EZ) and by definition, increase the redox potential of water. This allows enzymatic reaction rates to happen at the speed of light or close to it. (Mae Wan Ho video alert.) If you live in a low-light situation or it is winter time, consider using a hot spring, volcanic bath house or a hot tub to augment your EZ by using the heat of each one to create a large EZ in your cells, which I describe next. The Fournier effect using warm and cold water is a great way to recharge a low redox potential. It uses heat and cold simultaneously to alter interfascial water in your cells to increase the EZ of water.
Brain cancer: Epigenetic or genetic?
Oncologist are looking at human somatic genes in the nucleus, when the real problem is the mitochondrial genes that allow us to handle electrons and protons from food and water properly to signal how the cell sees the outside world within.
Modern technology uses non-native EMF frequencies that dehydrate cells and up-regulate glucose metabolism and causes calcium efflux in cells. Now let us look at what that means with respect to brain cancer.
Thus, when this happens, normal mitochondrial electron transport (published in any biochemistry textbook) cannot occur normally. This leads these altered cells to develop a metabolic picture which is “typical” in cancer, which is called the Warburg effect. Bissell is credited with rediscovering this type of metabolism in breast cancer research. With a Warburg-type metabolism, cells do not generate ATP from the mitochondria normally, and instead, become dependent on cytoplasmic generation of ATP via aerobic glycolysis. This is a very different and very inefficient way of transferring energy around a cell, but it is fast. Rapidly growing cells need energy delivered quickly. This is why this pathway is chosen. The primary driver of this “metabolic reprogramming” is the transcription factor called Hypoxia Inducing Factor 1 alpha (HIF-1α). HIF-1α normally only activates Warburg-type metabolism when oxygen levels are low. Hypoxia-inducible factor (HIF)-1, has an α-subunit and a β-subunit. It is a sequence-specific DNA-binding transcriptional complex protein that regulates genes involved in angiogenesis, glucose metabolism, cell proliferation and invasion/metastasis. This protein links oxygen tensions to cancer generation in cells. Oxygen levels in tissues are low when we are dehydrated naturally. Non native EMF dehydrates cells of both intracellular and extracellular water. It also releases calcium from the cells endoplasmic reticulum and lowers magnesium levels dramatically. When oxygen levels are lowered in intra or extracellular water, it acts differently chemically than it does under normal conditions. The chemistry of water, in this case, carries a lower oxygen tension. Most oncology research never studies the effect of intracellular water in cancer, but every MRI scan done on brain cancer shows an altered water response in their images. This is why in the redox Rx I told you MRIs are extremely valuable to the astute clinician. The brain and spinal cord are enveloped by CSF made from this water. CSF is 99% water by volume. This water comes from the blood plasma. Within the CNS, CSF is made in the ventricular system. CSF is designed to turn over 4 times a day in humans. CSF water must be recycled for brain functioning to remain optimal. In today’s modern world, these factors in cells are under 24/7 assault. Water chemistry is very altered in all brain diseases. This is why neuro-degeneration and brain cancer are exploding in incidence and prevalence today.
Modern technology uses non-native EMF frequencies that dehydrate cells and up-regulate glucose metabolism and causes calcium efflux in cells. Now let us look at what that means with respect to brain cancer.
Thus, when this happens, normal mitochondrial electron transport (published in any biochemistry textbook) cannot occur normally. This leads these altered cells to develop a metabolic picture which is “typical” in cancer, which is called the Warburg effect. Bissell is credited with rediscovering this type of metabolism in breast cancer research. With a Warburg-type metabolism, cells do not generate ATP from the mitochondria normally, and instead, become dependent on cytoplasmic generation of ATP via aerobic glycolysis. This is a very different and very inefficient way of transferring energy around a cell, but it is fast. Rapidly growing cells need energy delivered quickly. This is why this pathway is chosen. The primary driver of this “metabolic reprogramming” is the transcription factor called Hypoxia Inducing Factor 1 alpha (HIF-1α). HIF-1α normally only activates Warburg-type metabolism when oxygen levels are low. Hypoxia-inducible factor (HIF)-1, has an α-subunit and a β-subunit. It is a sequence-specific DNA-binding transcriptional complex protein that regulates genes involved in angiogenesis, glucose metabolism, cell proliferation and invasion/metastasis. This protein links oxygen tensions to cancer generation in cells. Oxygen levels in tissues are low when we are dehydrated naturally. Non native EMF dehydrates cells of both intracellular and extracellular water. It also releases calcium from the cells endoplasmic reticulum and lowers magnesium levels dramatically. When oxygen levels are lowered in intra or extracellular water, it acts differently chemically than it does under normal conditions. The chemistry of water, in this case, carries a lower oxygen tension. Most oncology research never studies the effect of intracellular water in cancer, but every MRI scan done on brain cancer shows an altered water response in their images. This is why in the redox Rx I told you MRIs are extremely valuable to the astute clinician. The brain and spinal cord are enveloped by CSF made from this water. CSF is 99% water by volume. This water comes from the blood plasma. Within the CNS, CSF is made in the ventricular system. CSF is designed to turn over 4 times a day in humans. CSF water must be recycled for brain functioning to remain optimal. In today’s modern world, these factors in cells are under 24/7 assault. Water chemistry is very altered in all brain diseases. This is why neuro-degeneration and brain cancer are exploding in incidence and prevalence today.
LDL - diverse
In inflammatory situations such as brain or heart disease, there are changes in the water chemistry. Every time water density changes in the body, lipoproteins will also change. Lipoproteins are found in blood, of which water is an ultra filtrate. The CSF also comes from that plasma. So if a person is dehydrated for any behavioral or environmental reason, it has tremendous effects on water density in the CSF of the brain and in the blood. All lipoproteins are surrounded by “reverse water micelles”. When the ability to have a reverse water micelle is lost due to dehydration, the individual is in an inflammatory state. LDL particles become smaller and dense and begin to carry more triglycerides.
Is meat unhealthy?
Essentially, what constitutes a healthy diet varies from person to person. It is the genes of the individual that decide what is healthy. While one person becomes ill from eating meat, another will stay healthy.
Meat is healthy for people with a particular genetic mutation. These people need high-quality protein from lean meat in order to metabolize fats. For such individuals, lean meat is the best way of preventing obesity. And they benefit from the fact that meat is an important source of various micronutrients such as Vitamin A, Vitamin B12, folic acid, zinc, selenium and iron. Folic acid, which is vital to health, and iron have a ten times greater bioavailability than, for example, is contained in vegetables. So these are highly valid reasons for people to eat meat.
The type of person who should avoid meat has a contrary genetic mutation on this particular DNA segment. A mutation that leads to a lack of stomach acid and of digestive enzymes – the so-called alkaline phosphatases. Regular consumption of meat by such individuals gives rise to a number of metabolic diseases including diabetes and hypertension. Here too, a gene check can answer the question as to whether meat is healthy for you or might even make you ill.
Meat is healthy for people with a particular genetic mutation. These people need high-quality protein from lean meat in order to metabolize fats. For such individuals, lean meat is the best way of preventing obesity. And they benefit from the fact that meat is an important source of various micronutrients such as Vitamin A, Vitamin B12, folic acid, zinc, selenium and iron. Folic acid, which is vital to health, and iron have a ten times greater bioavailability than, for example, is contained in vegetables. So these are highly valid reasons for people to eat meat.
The type of person who should avoid meat has a contrary genetic mutation on this particular DNA segment. A mutation that leads to a lack of stomach acid and of digestive enzymes – the so-called alkaline phosphatases. Regular consumption of meat by such individuals gives rise to a number of metabolic diseases including diabetes and hypertension. Here too, a gene check can answer the question as to whether meat is healthy for you or might even make you ill.
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